Insulin Resistance: The Increased Risk of Cancers
Insulin Resistance: The Increased Risk of Cancers by Leszek Szablewski Chair and Department of General Biology and Parasitology, Medical University of Warsaw, Chałubińskiego 5 Str., 02-004 Warsaw, Poland Curr. Oncol. 2024 , 31 (2), 998-1027; https://doi.org/10.3390/curroncol31020075 Submission received: 24 November 2023 / Revised: 15 January 2024 / Accepted: 10 February 2024 / Published: 13 February 2024 Download keyboard_arrow_down Browse Figure Review Reports Versions Notes Abstract Insulin resistance, also known as impaired insulin sensitivity, is the result of a decreased reaction of insulin signaling to blood glucose levels. This state is observed when muscle cells, adipose tissue, and liver cells, improperly respond to a particular concentration of insulin. Insulin resistance and related increased plasma insulin levels (hyperinsulinemia) may cause metabolic impairments, which are pathological states observed in obesity and type 2 diabetes mellitus. Observations