Na+ channel dia 300m^-2 in squid axon
Ca+ current is slower than Na+ current
Resting potentials(sp pump) then depolarized(enter Na to cell) then Action potential then Neurotransmitter then Communication
Action Potential(AP) Alteration tend to heart desease, cardiac arithmia, death
AP of heart recorded to produce ECG
An action potential is sequence of changes in the voltage across a membrane
Food: Black Cumin(+), mouri, betel leaf(++)
When Na, Cl, Ca enter then K leave cell for better heart contraction
3 ion Na enter to cell then 1 ion Ca leave the cell
2 ion K enter the cell then 3 Na out
1 ion Na In then 1 ion H out
Most of passive current carried by K+
Greater the Na gradient the more glucose enter to the cell
If Na out of cell is low the glucose transport stop
Na Glucose symporter lay on SP pump
50 million sp pump in each cell of kidney
Increasing Volt cause more Na chennel open
High Ca can damage mitocondria and increase oxidative stress
Na flow into rod outer segment
Na chennel of eye is open but close due to increase Ca
First vitamin reduce glucose if vitamin is low
then Na reduce glucose if Na is low
then insulin reduce the glucose
When vitamin is low to low the glucose then insuline secrete Nacl
receptor in mouth for test
The Na chennel called Enac that blocked by drug
Na for kidney to filter waste product
In dark Ca chennel is hi,
glutamate release hi in light Ca chennel is reduce, glutamate release is reduce
Na enter to cell is hi in dark than light
ECF: NaCl,Ca, Glucose,Hco3
Icf: K,mg,po,Protien Increase Ca active the Na Ca Exchanger Increase Na active SP pump Increase Cause cell death
K channel open to close Ca channel Dichlofenac sodium for Ca pump out from cell to contract mscle In early dev of organ AP Carried by Ca current than Na current
Boron:
For proper absorbtion of Ca
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